肥大细胞在金黄色葡萄球菌肺炎中的作用及功能调控

肥大细胞参与免疫调节，在细菌性肺炎的发病中起着重要作用，但其作用机制仍有待阐明。本课题将利用肥大细胞缺陷小鼠（c-kit wsh-/-）建立金黄色葡萄球菌性肺炎模型, 探讨肺部肥大细胞在金葡菌性肺炎中的作用，并深入阐明细胞表面C-kit受体及下游信号通路分子对细胞功能的调控机制。同时评估C-kit激动剂干细胞因子和抗菌肽CRAMP在金葡菌肺炎治疗中的作用。该研究将揭示肥大细胞在金葡菌感染免疫中的关键作用，有助于寻找金葡菌性肺炎新的干预靶点，为疾病治疗提供新的手段。

Mast cells, participating in the immune regulation process, play a role in the pathogenesis of bacterial pneumonia, but their underlying mechanisms are still unclear. Using a mast cell-deficient mouse （c-kit wsh-/-）model of staphylococcal aureus pneumonia, our research will reveal a new protective mechanism for mast cells in staphylococcal aureus pneumonia, and demonstrate the regulation of C-kit and its downstream signal molecules in mast cell function. In addition, the effects of a C-kit stimulator, stem cell factor, and an antibacterial peptide CRAMP on treatment of staphylococcal aureus pneumonia will be investigated. Our study will illustrate a key role of mast cells in host immunity against staphylococcal aureus infection and then provide novel intervention targets for this disease.