中药挥发油易挥发、稳定性差，是困扰含挥发油制剂质量与应用的关键问题。Pickering乳化包合技术为中药挥发油稳定化提供了一种新的方法。本课题提出“基于Pickering乳化包合原理，构筑以纳米颗粒膜包覆稳定的高载油固体复合粒子，实现中药挥发油的固体粉末化与稳定化”的科学假说。然而，如何实现高载油Pickering乳液的构建以及由“混悬态”到“粒子态”的固体化，避免乳核固体化过程中的损伤作用，是中药挥发油Pickering乳液固体粒子化的难点。为此，本项目创新阐释高分子聚合物与纳米颗粒双重稳定的中药挥发油Pickering乳化包合机理与“粒子网”屏障稳定机制，阐明Pickering乳滴雾化造粒的成型原理，建立中药挥发油Pickering乳核固体粒子化技术方法与稳定策略，并探索其口服固体制剂化应用原理与方法。本研究将为实现挥发油固体粉末化与稳定化提供新方法，为中药挥发油固体制剂应用提供参考。

The volatile property and poor stability of volatile oil are the key problems that plagued the quality of traditional Chinese medicine preparation. The Pickering emulsification technology provides a new method for the stabilization of volatile oil of traditional Chinese medicine. Based on the principle of Pickering emulsification, we set up a scientific hypothesis that the stable solid composite particles with high oil loading, coated by solid particles, can achieve solidification and stabilization of volatile oils from traditional Chinese medicine. However, how to achieve the construction of Pickering emulsion with high loading ability of oil, and solidification of Pickering emulsion of volatile oil from "suspended state" to "particle state" and avoid damage of solid particles stabilizer during drying is the difficulty of solidification of Pickering emulsion. Therefore, this study will elucidate the mechanism of emulsification and barrier stabilization of polymer modifing nanoparticles used for volatile oil Pickering emulsion, and explain the forming rules on solidification of Pickering emulsion, establish the technology method and stabilization strategy of solid composite particle loading Pickering emulsion of volatile oil, and explore its application in oral solid preparation. This study will provide a new method to the solidification and stabilization of volatile oil of Chinese medicine, and provide a theoretical basis for the application of the solid formulation of volatile oil of Chinese medicine.