仿生纳米机器人可以从环境中获取能量并转化为动能，完成复杂、环境相关的任务。在生物相关研究领域有重要的应用前景，特别是在精准生物医疗领域，实现诊疗、传感、成像、靶向递送一体化。纳米机器人研究领域受到广泛关注并已进行多年，取得了一系列令人瞩目的成就。但其中仍存在如下亟待解决和深入研究的重要科学问题。第一、纳米机器人的设计依托于不对称（Janus）粒子结构，高效构筑Janus粒子是本领域的核心问题。第二，纳米机器人的功能依靠化学结构的设计，功能化集成是重要问题。金属有机框架材料（MOF）具有高比表面积、尺寸可调的纳米孔道、催化性能。基于MOF材料构筑的仿生纳米机器人将在应用中具有突出优势。本项目拟使用聚合诱导自组装方法高效制备基于MOF的纳米机器人。为纳米仿生机器人的制备提供新思路和新途径，具有重要科学意义。

Biomimetic nano-robots harvest energy from the surrounding environment and convert it into motions. These nano-robots can navigate in complex biological media, thus have great potentials in biomedical apllications, including localized diagnosis, imaging, and therapy. Tremendous efforts have greatly enhanced the motion control, capability, and functionality for nano-robots. The construction of nano-robots is based on the fabrication of Janus particle. Yet, the efficient fabrication of Janus particle remains challenging. And the structural and functional complexity is another critical goal to achieve. Metal-organic frameworks (MOFs) have shown great potentials in many research fields, due to their high external porosity, huge surface area, and functionality as catalysts. Here, we introduce the synthesis of Janus MOF-based nanorobot by polymerization-induced self-assembly. The new approach may serve as a novel and versatile way for the production of nano-robot (Janus nanoparticle). The marriage of MOF and nano-robot may provide opportunities for many new applications.