SIGIRR是新近发现的TIR家族新成员，其通过负调控TLRs信号通路引起的炎症作用而在机体免疫调节中发挥重要作用。目前，有关鱼类SIGIRR对巨噬细胞炎症反应的效应及调控机制尚未见有关报道。本项目选择我国特别是我国南方地区重要的海水养殖品种鲈形目鱼类卵形鲳鲹（Trachinotus ovatus）为研究对象，从组织水平、细胞水平、分子水平研究SIGIRR的表达模式、对巨噬细胞炎症应答的影响, 以及SIGIRR调控炎症应答的作用机制。该项目的研究成果将阐明卵形鲳鲹SIGIRR在巨噬细胞中抗炎症作用及调节机制，为鱼类病害免疫防治提供理论和策略。

Single immunoglobulin interleukin-1R- related molecule (SIGIRR), a novel member of Toll-Interleukin-1 receptor family, involves in negative regulation of inflammation caused by Toll-like receptors signaling and plays important roles in immune regulation. So far, the research on the SIGIRR and their effects on macrophage and regulative mechanism are limited in fish species. This project selects Trachinotus ovatus, an economically important marine culture fish species in southern China, as research material and analyzes the SIGIRR expression pattern in tissues, investigates the effects of SIGIRR on inflammation and its regulation mechanism. The results will elucidate the anti-inflammation and regulative mechanisms of SIGIRR in macrophage and provide new insights into controlling and preventing fish diseases.