基于fMRI的不同频率tVNS调节经前期焦虑障碍脑网络的研究

经前期焦虑障碍（PMDD）为一种严重影响妇女健康的情感障碍性疾病，其发病的关键环节在情感脑中枢。我们前期研究发现，轻型PMDD（经前期综合征）患者存在情感中枢的异常。经皮迷走神经刺激（tVNS）对情感中枢的调节作用显著，故tVNS治疗PMDD的前景广阔。然而，tVNS治疗疾病时是选用高频还是低频刺激尚存争议。因此，探索不同频率tVNS对PMDD患者情感中枢的影响，有助于发现tVNS干预PMDD的合适频率。本项目围绕“PMDD患者对高低不同频率tVNS干预具有不同中枢响应特征”的研究假说，运用fMRI采集PMDD患者于低频（2Hz）和高频（25Hz）tVNS干预前后的数据，应用ReHo、ALFF、FC、ICA、Granger等数据分析方法，观察不同频率tVNS对PMDD患者情感中枢的影响，从脑网络层面探索tVNS干预PMDD的合适频率，为促进tVNS治疗PMDD提供有价值的影像学依据。

Premenstrual dysphoric disorder (PMDD) is a kind of affective disorder which seriously affects women's physical and mental health, the key onset of its pathogenesis is closely related to the emotional center. Our previous study showed that as the mild form of PMDD, premenstrual syndrome (PMS) had abnormal emotional center. It is well known that transcutaneous vagus nerve stimulation (tVNS) has significant regulatory effects on emotional center, so the prospect of tVNS in treating PMDD is vast. However, the choice of high-frequency or low-frequency tVNS in treating disease remains controversial. Thereby, the work of exploration the impact of different frequency tVNS on PMDD patients's emotional center may help to find out the appropriate tVNS intervention frequency for PMDD. This project focuses on the research hypothesis of "PMDD patients have different characteristic central responses to high or low frequency tVNS intervention ". The fMRI technique was uesed to collect brain data of PMDD patients before and after low-frequency (2Hz) and high-frequency (25Hz) tVNS interventions. Based on the regional homogeneity, amplitude of low-frequency fluctuation, functional connectivity analysis, independent components analysis and granger methods, we can analyze the influence of different frequency tVNS on emotional center of PMDD patients, which is a special procedure to explore the appropriate intervention frequency of tVNS on PMDD from the brain network level, we expect this study would provide valuable imaging evidence for promoting the clinical application of tVNS in the treatment of PMDD.