对于具有手性中心的外消旋底物，要实现从动力学拆分到动态动力学拆分的转变，最为关键的因素是对映异构体可否消旋及其消旋速率。基于RuPHOX的高效催化性能和碳骨架改变异构化消旋未引起关注的前提，本申请设计了几类基于动态动力学拆分的RuPHOX-Ru催化不对称氢化反应。进而，申请者将异构化消旋和手性脱除两种方式相结合，设计RuPHOX/Pd催化新反应以构建新的手性骨架。申请者已做了大量的前期研究，包括外消旋底物的合成以及不对称催化反应尝试等，均取得了预期的效果。特别是黄烷醇的不对称催化合成，已取得了高达97% ee及20/1 dr的立体选择性。本申请所设计的基于动态动力学拆分的不对称催化反应在理论和技术上得到充分的支持，显示很好的可行性。今后的工作是提升反应效果和拓展底物的适用范围。研究工作有望进一步拓展基于动态动力学拆分反应的范围，发展更为丰富的官能化手性化合物。

For a racemic substrate with chiral centers, the most important factor in achieving the transition from kinetic resolution (KR) to dynamic kinetic resolution (DKR) is the feasibility of racemization of the enantiomers and the rate of racemization. Based on the premise of the highly efficient catalytic performance of RuPHOX and the fact that less attention has been focused on racemization accompanied by changes in the carbon skeleton, this applicant has designed several types of asymmetric hydrogenation reactions based on dynamic kinetic resolution catalyzed by RuPHOX-Ru. Furthermore, the applicant has designed novel protocols catalyzed by RuPHOX/Pd for the construction of new chiral skeletons by combining isomerized racemization and the removal of chirality. We have conducted preliminary studies concerning the synthesis of racemic substrates and asymmetric catalytic reactions, and obtained promising results. In particular, the asymmetric catalytic synthesis of flavanols was achieved with up to 97% ee and more than 20/1 dr. The asymmetric catalytic reactions based on dynamic kinetic resolution described in this application are fully supported theoretically and technically, and are of good feasibility. Further work concerns improving the asymmetric catalytic behavior and exploring the substrate scope. The research is expected to further expand the scope of dynamic kinetic resolution reactions and allow for the development of a diverse range of functionalized chiral compounds.