中药复方是中医辨证论治具体体现和治病最常用法，中药药对(黄芪与红花等)是复方功能的核心配伍(小复方)，其体内动态整体调节整合效应反映在药动学(PK)与药效学(PD)。以往单一成分PK研究模式难以适合复方多组分特征的PK研究。. 在前期研究基础上，基于整合PK与PD、药物相互作用理论与方法，制作脑缺血损伤动物模型，以益气活血经典方-黄芪红花及其多组分组方为工具药，LC-MS、NMR等测定分析不同时相含药血浆或脑微透析液的指纹图谱、组分浓度、代谢产物与体外成分，并全局性表征；测定与PK同步的芪红多重PD指标(PET脑缺血图谱、ATP、Glu、Bcl-2、IL-1β等)；构建多组分谱效相关和整合PK-PD关联模型。阐释芪红多组分抗脑缺血的动态交互整合过程(PK特征)、药效物质基础、芪红配伍原理和作用机制，指导临床精准用药，建立适合中药多成分整合PK-PD研究模式，为中药PK等研究提供方法。

Traditional Chinese medicine (TCM) is the most common method to prevent and treat diseases. Chinese medicine pairs (such as Astragalus membranaceus and safflower) are the core compatibility of the compound (small compound) function, and their integrated effect of dynamic global regulation in vivo is reflected in pharmacokinetics (PK) and pharmacodynamics (PD). The previous PK research model of single component was not suitable for PK research of multi-component characteristics of TCM prescription.. Besides the preliminary research basis, new study is also based on the integration of PK and PD, theories and methods of medicine interaction. The animal model of cerebral ischemia injury was established, and the Yiqi Huoxue classic prescription -- astragalus membranaceus-safflower and its multi-component formula are used as the tool medicine. LC-MS and NMR are used to determine and analyze the fingerprints, component concentrations，metabolites and in vitro components of plasma or cerebral microdialysis fluid containing different time phases, and determine the global characterization. Simultaneous determination of multiple PD indexes of astragalus membranaceus-safflower with PK (PET cerebral ischemia figures, ATP, Glu, Bcl-2, Il-1β, etc.). The multi-component spectral effect correlation and PK-PD correlation model are constructed. Furthermore, the dynamic interactive integration process (PK characteristics) of astragalus multicomponent-safflower against cerebral ischemia, the pharmacodynamic material basis and the compatibility principle and mechanism of astragalus multicomponent-safflower, which will explain to guide clinical precision medicine use, establish a research model suitable for the integration of multiple components of traditional Chinese medicine PK-PD and provide methods for the research of traditional Chinese medicine pharmacokinetics.