中药是多组分复杂体系。目前,中药药代（PK）多套用西药单成分PK研究方法；方剂配伍研究多停留在拆方、药效、化学成分等层面,难以反映中药多组分相互作用（DDI）、PK特征。 . 突破中药PK研究的传统模式，以DDI、方剂"七情"为指导，借助PK、PD原理和LR、ANN数理方法,重点从附甘多组分的药代性、药理效应性相互作用角度,结合药物吸收、生物转化研究。制作大鼠心衰、Caco-2细胞、Fa2N-4细胞模型,以附甘组分系列配伍方为对象，HPLC、LC-MS测定、表征不同时相动物血液乌头碱、甘草次酸等；同步动态检测大鼠心功能、血流动力学、心肌氧化、炎症、室性早搏药理指标；构建多组分PK、PD、PK-PD模型。 . 结合前期研究，逐步建立反映中药多组分PK、PD特征、方剂配伍研究新方法；实现从DDI、PK等角度探讨附甘"减毒强心"机制、配伍原理和寻求最佳组方的目标。对方剂PK、配伍规律研究有重要科学价值。

Traditional Chinese medicine is a complex multi component system. At present, Chinese medicine pharmacokinetic (PK) paraphrase the research methods of western medicine Single ingredient PK, and most of prescription compatibility study stay in the demolition party, efficacy, chemical composition and other aspects, which is difficult to reflect the chinese medicine multi-component interactions (DI) and PK characteristics. Breakthrough the traditional PK research model of Traditional Chinese medicine. Based on DI, prescription seven emotions. By the principle of PK and PD. Introduction of LR, ANN and so on mathematical methods. Focus from the monkshood and licorice multi-component drug interaction between the pharmacokinetics of the pharmacological effects, combined with drug absorption and biological translational research. Making rat heart failure, Caco-2 cells, Fa2N-4 cell model. Monkshood and licorice component series compatibility as an object, to measure aconitine, glycyrrhetinic acid and other ingredients in animal blood in different time with HPLC、LC/MS, synchronous dynamic test effectiveness indexes in rats such as cardiac function, hemodynamics and myocardial oxidation, inflammation, premature beat, and build the multicomponent PK and PD, PK-PD models. Combined with previous research, and gradually establish reflect the PK,PD characteristics of Chinese traditional medicine multi-component, and the new methods of herbal research. Realization of monkshood and licorice " attenuated toxicity and strong heart" mechanism from DI, PK angles, compatibility principles and to seek the target of the best formula, which has important scientific significance in prescriptions for PK and compatibility research.