双官能团手性催化剂具有高活性和高选择性等优良特性，特别是含有Lewis酸和氢键给体活化位点的双官能团手性催化剂应该更接近于酶催化。本课题以天然氨基酸为基本手性源，设计并合成一些新型双官能团手性配体，用于改进传统有机反应并发展新型有机反应及相关天然产物类似物的合成。同时，将发展的双功能团均相手性催化剂通过纳米金属或者金属有机超分子（MOF）负载，努力实现手性催化剂的回收和循环利用，提高反应转化效率。此外，将发展的双功能团配体通过金属离子结点组装成 MOF，并生成手性孔道，诱导出微手性环境，同时将纳米金属引入孔道，既能实现不对称转化又能充分利用纳米金属较高的催化效率以及MOF孔道对反应底物的高选择性。总之，通过双功能团手性配体的设计和合成，模板负载，纳米催化的协同使用，MOF 后修饰模版手性催化等有机组合，将不对称有机合成提高到一个新的层次。

The bifunctional chiral catalysts have two features,that is, high catalytic activity and high selectivity. Especially, those bifuncational chiral catalysts containing Lewis acid and H-bond acivating sites are mimics of some natural enzymes. This project aims to design and synthesize some new bifunctional chiral ligands to improve the traditional reactions and to develop some new reactions. Meanwhile, the reuse of the catalysts will be reached by the loading of the catalysts on the nano-metals or metal-organic frameworks (MOFs),increasing the TON. Besides,the ligands were assembled into MOFs with the metal ions as nodes, generating chiral cavities as the chiral micro-reactor. At the same time, the metal nanoparticles are encapsulated into the cavities to both catalyze asymmetric conversion and enhance the catalytic efficiency as well as the selectivity of the reaction substrates. Overall, the synergetic combination of the bifunctional catalysts,the template loading, the employment of nano-metals and the postsynthetic modification of MOFs will improve the asymmetric organic synthesis remarkably.