手性物质广泛存在于天然产物和药物中，不对称催化与合成是有机合成化学家的永恒主题，同时绿色合成与制备更是时代赋予合成化学家的使命。两者的结合正是有机合成化学家的当今重要任务之一，并具有很大的挑战性。水作为一种便易、易得的溶剂具有常见有机溶剂不具有的安全、无毒、无害、环境友好的优点，被人们认为是理想的反应介质，因而水相有机不对称反应是绿色化学的重要研究内容之一。但是，除相转移催化剂以外，几乎所有手性小分子催化剂以及手性金属催化剂，对水的容忍性非常有限。经常微量水的存在导致这类催化剂的失效。为了解决这一难题，我们打算在本课题组之前的研究工作基础上，合成多种多样的耐水手性氨基酸衍生物作为手性配体，并与模板负载的纳米金属相互兼容，协同作用，实现水相不对称反应，达到一加一大于二的协同效果。探索不同种类纳米金属与不同氨基酸衍生配体协同效应，并应用这种协同催化拓展水相不对称有机反应的范围，发展水相有机新反

The chiral moeities exist extensively in natural products and medicines. The asymmetric synthesis is the permanent theme of the organic synthetic chemists. At the same time, green synthesis is a mission of the age to the synthetic chemists. The combination of this asymmetric synthesis and the green synthesis is one of the current crucial tasks, which challenges the chemists. Water as a kind of solvent can take many advantages, such as cheap, non-flammable, non-toxic, harmless and environment friendly, which are unavailable for the organic solvents. As a result, water is a kind of ideal reaction medium and the reaction in water is taken as one of the important contents of green chemistry. However, except for phase transfer catalysts, either chiral small molecules or chiral metal catalysts hardly survive in water. Especially for chiral metal catalysts, water is fatal to the most of these catalysts. In order to solve this problem, we attempt to synthesize a variety of water-resistant catalysts derived from amino acids based on the previous research work in our laboratory, consisting and coordinating with nano-metals loaded on the various templates. Then we explore the synergetic effect between this chiral amino acid derivatives and the loaded nano-metals. And we apply this effect in the new reactions and new catalytic models in water to develop asymmetric synthesis in water. Fianlly, we want to raise the level of the green chemistry.