3,4-二氢-2(1H)-喹啉酮是一类非常重要的结构单元，广泛存在于许多生物活性物、天然产物和药物中。但是，目前该类化合物的合成方法较少，且产物取代类型单一，合成方法局限性大。在先前的工作中，我们已经发展了一些新的自由基串联反应，将其应用于氧化吲哚合成中。基于该前期工作，结合目前3,4-二氢-2(1H)-喹啉酮的合成研究现状，本项目计划从易制备的邻位不饱和基团取代的N-芳基丙烯酰胺出发，发展一类过渡金属催化的新型串联反应，将不同类型的官能团引入产物结构中，合成多取代的3,4-二氢-2(1H)-喹啉酮。同时，通过对不同类型底物的反应体系研究、串联路径选择性调控及机理的探索，进一步深入理解和拓展这类反应，为喹啉酮合成和串联反应等研究领域提供一定的实验依据和理论基础。

3,4-Dihydroquinolin-2(1H)-one is an important structure subunit found in a wide range of biologically active compounds, natural products, marketed drugs, and drug candidates. However, in contrast to the development of synthetic approaches for other heterocycles, methods for constructing 3,4-dihydroquinolin-2(1H)-ones are limited, and suffer from narrow functional group compatibility, poor atom economy, and the necessity of using complicated starting materials. We previously have developed some novel cascade reactions for the synthesis of substituted oxindoles. Based on our previous work, we propose to develop a new, efficient method for the construction of multi-substituted 3,4-dihydroquinolin-2(1H)-ones via transition metal catalyzed cascade reactions of N-arylacrylamide with unsaturated substituents at the para-position. A systematic investigation will be carried out on reaction factors, including transition metal salts, oxidants, and unsaturated substituents of N-arylacrylamides. Mechanism of this reaction will be studied. Our work will establish a new synthesis of multi-substituted 3,4-dihydroquinolin-2(1H)-ones and provide insights of transition metal catalyzed cascade reactions.