氰基是一类重要的基团，可以进行较多的反应。其中，对氰基的加成是合成酮化合物的一种重要方法。近年来，过渡金属催化对氰基加成成酮的方法由于避免了传统锂试剂和格氏试剂加成的一些局限，已然成为了一个研究热点。但是，目前该领域的研究主要集中在单键构建的反应，与之相关的过渡金属催化的串联反应研究相对滞后。本项目结合当前该领域的研究现状，根据过渡金属促进对氰基加成存在碳金属键的插入及自由基加成两类不同机理，将碳碳双键或三键引入反应，增加反应位点，有针对性的设计和发展一些过渡金属催化的包含对氰基加成的串联反应合成环酮类化合物。通过对催化体系建立、立体选择性研究、以及反应机理的探索，进一步深入理解和研究这类串联反应。为环酮化合物的合成提供一个更为灵活的新途径；同时，也为该领域及过渡金属催化串联反应的研究提供一些实验和理论依据。

The nitrile group is widely used in synthetic organic chemistry. In recent years, transition-metal-catalyzed addition reactions to nitriles have been developed as efficient approaches for the synthesis of ketones. These reactions exhibit many advantages such as high functional group tolerance and mild conditions compared to the classical Grignard reaction. However, most studies in this field focused on classic one-bond-forming reactions. On the other hand, cascade reactions can offer more environmentally benign and atom-economical processes. Based on two types mechanism of this addition, insertion of nitrile group from metal nucleophile and radical addition, we propose to develop some novel transition-metal-catalyzed cascade reactions, which include addition of nitrile group, to synthesize carbonyl group-containing heterocyclic compound. In this project, improving the reaction efficiency, expanding the substrate scope, exploring catalytic mechanism, and developing asymmetric catalytic method will be carried out. Our work will supply the experimental and theoretical basis for these research fields and provide insights of transition metal catalyzed cascade reactions.