氮中心自由基的环化是构建含氮杂环化合物的一个重要策略。该领域中，亚胺自由基参与的串联环化反应研究发展缓慢，尤其是分子间的串联环化。本项目根据这类反应研究较少、类型单一、体系不环境友好等现状，结合自由基对氰基加成产生亚胺自由基的过程有着能形成新的化学键、能导入新的官能团等特点，有针对性的设计多活性位点的氰基底物，发展一些亚胺自由基参与的分子间串联环化反应。通过对反应体系的建立和机理的探索，进一步深入理解和研究这类反应，为其在构建复杂含氮杂环的应用中提供一定的实验依据和理论基础。

Cyclization of active nitrogen-centered radicals is one of the important strategies for the synthesis of N-heterocycles. However, most studies in this field focused on one-bond-forming reactions, the examples of iminyl radicals involved cascade cyclizations are very rare, especially intermolecular reaction. Radical addition to nitrile is an approach for generating iminyl radicals, and provide great opportunities for the formation of carbon–carbon and carbon–heteroatom bonds. In this proposal, some novel iminyl radicals involved intermolecular cascade cyclization reactions will be developed for the synthesis of N-heterocycles. Improving the reaction efficiency, expanding the substrate scope, and exploring reaction mechanism will be carried out. Our work will supply the experimental and theoretical basis for this research fields.