材料的修复可延长其使用寿命。材料中预先设计的可逆共价键或超分子作用是实现修复的关键。生物酶可高效催化各类生化反应，其有望通过触发材料内的生化反应或改变材料所在的物理化学环境以实现材料在结构及性能方面的修复。利用酶促反应调控高分子及杂化材料的修复将在很大程度上拓展可修复材料的概念及范畴，简化或优化修复过程并高效恢复材料各方面性能。本项目旨在开发新型的具有酶促反应可调修复性能的高分子体系：选择多组酶促反应以诱导可逆作用力的断开及重新结合；将酶及可逆作用力通过组装或修饰等方法引入体系，调控制备参数，从而根据需求制备出不同种类的可修复高分子及杂化材料；研究其受损后的刺激响应性修复能力，并对比有无酶参与时材料的修复能力及修复前后材料性能的差异。探索该类材料在生物医学工程领域的潜在应用，并探索酶促反应在其他刺激响应性材料制备及功能实现中的应用，推动酶参与的新型功能性高分子材料的开发及全面应用。

Healable polymer or hybrid materials have excellent performances in extending service life, improving reliability and reducing raw material consumption. The reversible interactions stored in these materials are key for the healing process. Enzymes, that efficiently catalyze various biochemical reactions, have the potential to trigger the cleavage and reformation of the reversible interactions, therefore promoting the healing of polymer materials. The enzyme-regulated healing of polymer or hybrid materials, that utilizes the biochemical reactions for the restoration of the properties of functional materials, is a great extension of the concept of self-healing/healable materials and may also facilitate the healing process. These materials are promising to be applied in the field of biomedical engineering. The aim of this project is to develop novel polymer materials capable of healing damages on demand, mediated by enzymatic reaction. The enzymes and enzymatic reactions, as well as the reaction-induced physicochemical environment changes, will be studied and several suitable enzyme catalysis systems will be selected to induce the cleavage and reformation of chemical bonds or supramolecular interactions. The suitable enzymes and chemical bonds or supramolecular interactions will be introduced to the polymer systems for the fabrication of enzyme-containing healable polymer materials. The synthesis parameters will be adjusted according to the requirements, and various types of enzyme-containing healable polymer or hybrid materials, including elastomers, free-standing films, hydrogels, and coatings, will be fabricated for different applications. The properties (e.g., morphologies and mechanical properties) and stimulus-responsive healing abilities of the materials will be studied. Furthermore, the healing abilities of the healable polymer materials with and without enzymes, as well as their mechanical properties after healing, will be investigated in detail. Meanwhile, the potential applications of these materials in the field of biomedical engineering will be explored, and the self-regulated control of other stimuli-responsive materials mediated by enzymatic reactions will also be studied to promote the development of novel enzyme-containing functional materials.