生物大分子药物具有独特的结构、性质及功能，需要灵活的载体设计以满足其特定的递送要求。反应性聚合物可针对性结合其他分子而方便地获得所需功能，是实现生物大分子药物递释系统定制化设计的理想选择。本项目旨在根据生物大分子药物的特点，有目的性地对反应性聚合物进行功能化，在保留药物活性的基础上对其进行封装与运载，为反应性聚合物应用于药物传递领域奠定基础。首先研究生物大分子药物的结构、性质及功能，并有针对性地对反应性聚合物进行功能化修饰。进而研究功能化聚合物的自组装行为及对药物的负载、输送及可控释放能力，并归纳聚合物载体的结构及组成对生物大分子药物递送能力的影响规律。进一步利用反应性聚合物功能化制备一系列聚合物载体，并通过高通量筛选方法获得优化的聚合物载体用于生物大分子药物的高效递释。同时研究提高反应性聚合物生物相容性的方法，以促进反应性聚合物在生物医疗领域的全面应用。

Rational nanocarrier design according to the unique structure, property and function of therapeutic biomacromolecules is highly demanded to meet the specific delivery requirements. Reactive polymers, which can be readily endowed with desired functions by chemical modification with selected functional molecules, are ideal materials for the fabrication of customized nanocarriers for therapeutic biomacromolecule delivery. The aim of this project is to develop nanocarriers by rational functionalization of reactive polymers for the efficient encapsulation and delivery of therapeutic biomacromolecules while maintaining their bioactivity. First, the reactive polymers will be rationally functionalized according to the structures, properties and functions of given therapeutic biomacromolecules. The self-assembly behaviors of the functionalized polymers, as well as the therapeutic loading-release behaviors of the as-prepared nanocarriers, will be then studied systemically to understand how the architecture and composition of polymer nanocarriers affect the therapeutic delivery behaviors. Furthermore, a series of polymer nanocarriers with diverse functionalities will be fabricated by functionalization of reactive polymers in a well-defined manner, which allows for the high-throughput screening to identify the optimal nanocarriers for the efficient delivery of therapeutic biomacromolecules. Meanwhile, the strategy to improve the biocompatibility of reactive polymers will be developed to promote the applications of reactive polymers in the field of biomedical engineering.