内源性逆转录病毒（Endogenous Retroviruses，ERVs）是宿主基因组的重要组成成分，除了影响像鸡的隐性白羽等表型外，还影响宿主的免疫。前期我们通过LTRharvest、LTRdigest等生物信息分析软件，在鸡Gallus_gallus-5.0全基因组范围内系统鉴定出436个鸡ERVs，而其中位于1号染色体上的ERV3受禽白血病病毒J亚群（ ALV-J）的抑制不能表达。鸡ERV3与ALV-J可能存在互作，ERV3参与影响鸡感染ALV-J后发生免疫反应乃至白血病不断演化的过程。本项目拟研究感染过程中鸡ERV3和ALV-J的互作关系，阐明ERV3影响ALV-J感染进程中先天免疫反应的分子机制。这对阐明ERV参与宿主免疫反应影响疾病进程的分子机制，对 ALV-J 的防控以及培育我国具有自主知识产权的、有抗病能力的蛋鸡和肉鸡新品种均有重义。

Endogenous Retroviruses (ERVs) are important components of veterbrate genome. ERVs plays critical roles in animal performance such chicken recessive white phenotype. They further affect immunity of the host. In previous study, we identified 436 ERVs in chicken genome using Gallus_gallus-5.0 database with LTRharvest and LTRdigest, in which ERV3 located in chromosome 1 is repressed to express by ALV-J. We hypothesized that there is an interaction between the ERV3 expression and ALV-J infection of chicken. In this study, the interaction between ERV3 and ALV-J will be investigated. It's greatly significant for understanding the molecular mechanism underlying ERVs involved in innate immunity of host's anti-viruses, and for the chicken avian leukosis control and chicken breeding in disease-resistance.