针对当前占主导地位的超顺磁氧化铁纳米平台中存在的尺寸限制和磁学性能损失导致以其开发的磁性靶向热化疗剂在抗肿瘤诊疗一体化应用中不能满足临床需求的问题，本项目提出以新型的、具有优异磁学性质的涡旋磁氧化铁纳米环为平台，优化界面从而结合化疗药物顺铂并偶联抗体等靶向分子，构建高效靶向热化疗纳米制剂并用于肝癌诊疗。研究其多组分复合结构和诊疗功能之间的构效关系以及药物负载与热激活释放的关键技术；建立肝癌肿瘤裸鼠模型，评估该靶向热化疗纳米制剂在肝癌诊疗中的效果和优势; 阐明化学治疗、物理磁感应热疗和靶向治疗之间的相互作用以及治疗过程中量效特性。本研究的开展可望为高效靶向热化疗纳米制剂的构建提供理论和方法基础，为基于纳米制剂的肝癌诊疗一体化多学科综合治疗提供一个新的选择。

As the prevailing biomagnetic materials platform, superparamagnetic iron oxide (SPIO) has size limitation and weak magnetic properties, which in turn result in significantly reduced performance of SPIO based nanoagent in cancer thernoastic application. Here, we propose to construct an innovative tumor-targeting thermo-chemotherapeutic nanoagent based on novel ferrimagentic vortex-domain iron oxide (FVIO) for high performance hepatocellular carcinoma thernoastics. By rational design and optimization of interface, the FVIO is conjugated with PEI-g-PEG and VEGF/EGFR antibodies as well as loading cis-platinum as chemotherapeutic drug. We will study the structure and composition of nanoagent as a function of thernoastic properties, and the key factors for the drug loading and thermally activated release; establish hepatocellular carcinoma animal model using tumor-bearing nude mice to evaluate the enhanced efficacy of the nanoagent； understand the possible interaction and synergistic effect of chemotherapy magnetic hyperthermia and targeted therapy as well as the dose-response relationship. The results obtained from this project will not only provide a general strategy to construct a variety of high efficient FVIO based theronostic nanoagents that rely on heat induction, but also enable a safe and efficacious multimodality treatment for hepatocellular carcinoma in the future.