易转移和对化疗药物敏感性差是肝癌治疗难点。项目组从广西民间特色中草药，蒟蒻薯科,裂果薯属植物裂果薯中分离获得的裂果薯皂苷具有明显抑制人肝癌细胞增殖和血管生长的作用，并初步确定与抑制酪氨酸蛋白激酶有关，且毒性低，已获专利申请。本项目将围绕酪氨酸激酶的Ras-Raf-MEK-MAPK、PI3K/AKT和JAK-STAT信号通路，探讨裂果薯皂苷抑制肝癌和血管生长、转移的分子机制；比较各皂苷作用强弱；分析构效和各组分发挥作用的关系。本研究不仅有助于解决目前肝癌治疗的难点问题，也有望用现代医学、分子生物学技术揭示其中医治疗肝癌机理并为新型抗肝癌中药的研制提供理论依据和新思路。

Easy metastasis and poor sensitivity to chemotherapy is the difficulty in liver cancer treatment. Saponins from Schizocapsa plantaginea (Hance) Brenth, Schizocapsa, Taccaceae as natural produts from folk specialty medicine in Guangxi, isolated by our project team, which can significantly inhibit the proliferation of human hepatocellular carcinoma cells and angiogenesis with low toxicity, is preliminarily confirmed the mechanism of action to be related to inhibition of protein tyrosine kinase(PTK), and has obtained the patent application. This project will investigate the molecular mechanisms of saponins inhibiting the growth, metastasis of liver cancer and antiangiogenesis on the Ras-Raf-MEK-MAPK, PI3K/AKT and JAK-STAT signaling pathways related to PTK, compare the intensity of the action of each saponins, analyze the structure-activity relationship and components play a role. The study will not only help to solve the difficult problems of liver cancer treatment, is also expected to use modern medicine, molecular biology reveal its mechanism of Chinese medicine treatment of liver cancer and provide an important basis for the development of a new anticancer agent from herb and new ideas.