作为一种具有特殊性能的新型碳纳米材料，石墨烯的开发与应用不可避免的会通过各种途径释放到环境中去，对陆生和水生生物及人体的健康造成影响。本项目以石墨烯和氧化石墨烯为对象，采用14C示踪技术，在标记石墨烯和氧化石墨烯已成功合成的基础上，结合现代仪器分析手段，建立生物过程中石墨烯定量研究的方法，研究石墨烯进入生物体内的界面传输以及体内代谢、分布与残留等生物过程和毒性效应，揭示生物体内石墨烯和氧化石墨烯代谢、分布、赋存形态与毒性效应之间的内在关系；同时考察在生物体内富集的石墨烯的亲子传递规律及其对子代的影响，为石墨烯的环境风险评价提供关键科学基础。

Graphene exhibits exceptionally high crystal and electronic quality, and has already revealed a cornucopia of new physics and potential applications. If even a small fraction of its potential applications are realized, it is inevitable that it will enter environment systems in increasing amounts, while the risks it may pose are largely unknown. Using graphene and graphene oxide as the target and by means of carbon-14 tracer techniques, we will study the biological processes and effects of graphene and graphene oxide in typical organisms. The relationship between the toxicity of graphene and its metabolism, distribution and concentration in the organisms will be established. The study will also explore the potential maternal transfer of the bioaccumulated graphene in organisms and its effects on the offspring. The results here will provide significant scientific information for the environmental risk assessment of graphene.