卵巢早衰是妇科内分泌领域的常见病。发病率有上升趋势。在维医妇科疗效显著。在维医临床辨证诊疗中，异常黏液质型卵巢早衰检出率最高，但是其生殖生物学基础研究未见报道，限制着其治疗的标准化和现代化。项目组以维医体液论为切入点，以证候表征模型原则，在已建立的异常黏液质型大鼠模型基础上，造异常黏液质型卵巢早衰病证大鼠模型并系统评价，通过与西药顺氯氨铂诱导卵巢早衰模型以及西药顺氯氨铂诱导异常黏液质型卵巢早衰大鼠模型做比较对其生殖生物学特征、卵巢功能进行系统研究，并以特色药粘液质型复方木尼孜其颗粒自然对证和反证后加以评估；收集性腺轴和卵巢组织及外周血，通过性腺轴形态、神经内分泌相关激素、卵巢组织结构等一系列指标的比较分析，研究异常黏液质型卵巢早衰病证的形成与性腺轴神经内分泌调控网络及卵巢早衰相关信号转导通路功能改变的内在联系机制，揭示其本质，为该病证的实验研究、维药研发和维药物评价提供可靠的实验动物模型。

Premature ovarian failure (POF) is a common woman's endocrinal disease. There is an upward trend in incidence and significant efficacy in gynecology of traditional Uighur medicine. The detection rate of POF in abnormal balgham syndrome is highest in Uighur medicine clinical diagnosis and treatment, but its basic research of reproductive biology has not been reported yet, so it limitise its treatment of standardization and modernization.The research team as Uighur humoural theory if a breakthrough point, to follow model of syndrome characterization as modeling principle,based on the established balgham rat model ,to develop a POF rat model of abnormal balgham and to evaluate systematically. To study reproductive biological charecteristics and ovarian function systematically by compareing it with western medicine ：Cisplatin induced POF model and cisplatin induced POF model of abnormal balgham and to futher assassement by natural cross-check with traditional Uighur characteristic medicine balgham muniziq .To discuss innate related mechanisms between formation of abnormal balgham POF with gonadal axis neuroendocrine regulation network and with POF related signal transduction pathway function via comparative analysis of series parameters including morphology of gonadal axis, neuroendocrine related hormones,structure of ovarian tissues by collecting gonadal axis and ovarian tissues and peripheral blood ,to reveal its essence and to provide a reliable experimental animal model of the disease for experimental study,Uighur pharmaprojects and for Uighur drug evaluation.