多囊卵巢综合征可控危险因素研究

多囊卵巢综合征（PCOS）患病率较高，对女性影响远超出妇产科范畴，是一种全身代谢性疾病，且增加多种内科疾病风险。目前病因不清，治疗以对症为主难以解决根本问题。如从预防角度进行研究、发现其可调控的危险因素，并进行干预以降低发病率，效果将远较治疗可靠经济，对人群健康更有意义。通常认为代谢性疾病的可调控危险因素主要包括饮食、运动、环境等，因此我们假设PCOS的危险因素也可能与这些有关，但目前未见系统报道。本研究拟采用人群为基础的分层多阶段概率比例抽样（PPS）法对女性发病状况进行调查；选择符合研究地区饮食特点的问卷对其进行信度效度评价，使用前期经信度效度评估的体力活动问卷，并建立同时检测血清多种环境内分泌干扰物（EEDs）的方法，对人群饮食、体力活动及EEDs等可控因素与PCOS的关系进行多方位研究；获得各年龄段PCOS患病特征，并筛选出该病可调控危险因素，为下一步干预提供科学可靠可行的依据。

The prevalence of polycystic ovarian syndrome (PCOS) is relatively high. As a common endocrine and metabolic disorder, the adverse effect of PCOS on female is more than reporductive system and involve multiple internal disorders. Due to the unclear pathogeny, patients can't be cured completely by current therapy. If we could find its risk factors and control them, we might decrease its prevelence. This is more economical and effective compare to treatment. Generally speaking, risk factors for metabolic diseases containing nurition, excercise and environmental endocrine disruptors (EEDs). So we hypothesised that those risk factors might also be related to PCOS, while they are not investigated systematically In this study, probability proportionate size sampling (PPS) method will be used to investigate the prevalance of PCOS; a food frequency questionnaire will be validated and used for the target population diet intake, an international physical activity questionnaires which has been validated in our early study will be used to measure physical activity; a new sensitive and simple method of detecting several kinds of EEDs at same time will be established and used to measuring EEDSs in blood samples of participants. Risk factors will be screened by analysing above results and stratigy of PCOS prevention will be estabolished.