周围神经损伤是临床常见创伤，许多病例致伤后终生残疾。影响治疗效果的关键因素是损伤的神经是否得到良好的再生，而缝接技术是神经再生的最重要基础。本课题组在前期研究中利用周围神经选择性再生的特性，提出小间隙套接缝合技术，用以替代沿用近百年的神经外膜缝合方法。小间隙套管在动物实验及临床多中心研究中获得良好的效果，并已申请专利。本研究旨在将损伤神经小间隙套接缝合技术与药物缓释技术相结合，在小间隙套接缝合修复周围神经时，通过套接局部较长时间的缓慢释放药物（2-4周），促神经再生并提高周围神经修复效果。研究内容包括促神经再生缓释给药套管系统的制备研究、体外效应与作用机制研究和修复周围神经动物疗效的研究等。该研究是面向临床急需解决的重大治疗问题，通过相关新型给药系统研究和科学机制研究、建立新的治疗方法和策略

peripheral nerve injury is a common clinical traumatical disease, which at most time results in disability. The critical point affecting treatment effect is whether the injured nerve could have a fine regeneration, during which the suture technique is the most important basis for this process. Our group proposed small gap bridging suture technique taking advantage of the property of peripheral nerve selective regeneration, to replace epineurium suture method used for nearly a hundred years. The good results obtained in animal experiments and clinical multi-center study, and has applied for patents. This research aims at combining the small gap bridging suture technique with drug delayed release method to promote nerve regeneration and repairing effect through on site delayed release of drug(2 to 4 weeks) during the bridging period. The contents of this research include the preparation of nerve-regeneration promoting drug release tube system, in vitro effect and function mechanism, and animal experiment of peripheral nerve regeneration. This research which is directed to the major clinical problem, will establish new treatment and strategy through the referring research of new drug release system and its function mechanism.