临床工作中遇到周围神经长节段毁损性损伤存在用于修复的供体神经缺乏的问题。为此，本课题组长期致力于寻找有效扩增周围神经损伤修复潜能方法的实验研究。基于本课题组近几年的研究，我们证实了周围神经倍数再生的新生轴芽在神经修复过程中的临床意义。通过利用这样的倍数再生机制，使得临床上采用较为细小的神经来修复较为粗大的神经的可行性得到了科学实验的论证。并初步明确了在一般状况下倍数再生修复扩大率可达约3.3倍。前期实验工作已经发现smcx基因对周围神经雪旺细胞的细胞迁移、再生和触手生发起调控作用。本研究立足于这些前期研究结果，进一步探索神经倍数再生现象背后的分子信号调控机制。期待在倍数再生机制下，实现通过smcx基因调控周围神经倍数再生放大倍数，从而解决长期以来周围神经修复能力不足、损伤后缺乏神经供体以及周围神经纤维再支配靶器官不及时的临床问题。

In clinical practice, lack of proper nerve graft resource haunt orthopedic surgeons in solving problem such as long segment nerve injury. Therefore, our team has been dedicated to find a practical way to augment peripheral nerve repair potential for years. Based on our recent research, we proofed the significance of newly grown nerve sprout in peripheral nerve multiple regeneration. By incorporating peripheral nerve multiple regeneration mechanism, we demonstrated that utilizing minor nerve trunk to repair larger nerve trunk is clinically possible. Moreover, we demonstrated that the multiple repair rate of peripheral nerve multiple regeneration is roughly 3.3. Our previous experimental work has discovered that smcx gene take part in regulation of Schwann cell migration, regeneration and process development. Based on our extensive previous work, current study dedicated to further explore the molecular regulatory mechanism behind peripheral nerve multiple regeneration with hoping to aid refractory clinical peripheral nerve injury.