伴童年创伤抑郁症炎症系统活性和情绪相关脑区影像特征及其关联性研究

现有的研究证据表明童年创伤是抑郁症发生发展的显著危险因素，而伴童年创伤的抑郁症可能是抑郁症的一个重要功能亚型，拥有其独特的临床表现和生物学改变。尽管如此，目前有关它的发病机制仍不清楚。本项目在前期研究的基础上，试图通过比较伴与不伴童年创伤的抑郁症患者和健康对照血浆中主要促炎因子（IL-1β、IL-2、IL-6、IL-17、TNF-α、INF-γ）、抗炎因子（IL-4、IL-10）、C反应蛋白水平以及相关脑区磁共振数据，来分别阐明其炎症系统功能活性和情绪相关脑区影像学特征。尤其是澄清伴童年创伤的抑郁症患者炎症系统活性和情绪相关脑区结构与功能改变的相关性。同时结合受试者主要的人口学和临床表现特征，尝试寻找与伴童年创伤抑郁症患者相关的临床病理标记。本研究期望为伴童年创伤抑郁症发病的潜在生物学机制提供证据，并最终为这类抑郁症的临床诊断及治疗提供新的思路和科学依据。

The current evidence demonstrates that childhood trauma is a great risk factor for the development of depression, and depression with childhood trauma may be treated as a functional subtype of depression with unique clinical manifestations and biological alterations. However, to date, the pathogenesis of depression with childhood trauma remains confusing. Based on our previous research findings, the present study intends to elucidate the characteristics of inflammation system and brain imaging of emotion-related regions through comparisons of plasma levels of main pro-inflammatory factors (IL-1β、IL-2、IL-6、IL-17、TNF-α、INF-γ), anti-inflammatory factors (IL-4、IL-10), C reactive protein (CRP), and magnetic resonance imaging data in depression patients and healthy controls with or without childhood trauma. In particular, to clarify the associations of inflammation activity with structure and function of emotion-related brain regions in depression patients reporting childhood trauma. Simultaneously, combined these findings with demographic and clinical features, this study also tries to detect clinical and pathological markers in relation to depression patients reporting childhood trauma. The present study expects to provide information for revealing the potential biological mechanisms underlying depression with childhood trauma, and finally to provide new insights and scientific evidence in the clinical diagnosis and treatment of depression experiencing childhood trauma.