Neural correlates of childhood trauma with executive function in young healthy adults.
Neural correlates of childhood trauma with executive function in young healthy adults.
复制标题
童年创伤与年轻健康成年人执行功能的神经相关性。
DOI：
10.18632/oncotarget.20051
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发表时间：
2017-10-03
期刊：
影响因子：
--
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Lu S;Pan F;Gao W;Wei Z;Wang D;Hu S;Huang M;Xu Y;Li L
这项研究的目的是调查年轻健康成年人的童年创伤、执行障碍和静息状态脑功能改变之间的关系。有儿童期创伤的受试者24人，年龄和性别匹配的无儿童期创伤的受试者24人。执行功能通过一系列有效的测试程序进行评估。采用低频波动幅度分数法(FALFF)评价局部脑活动，并比较两组间的差异。在随后的功能连通性分析中，进一步选择具有改变的fALFF的区域作为种子。此外，还分析了FALFF和连接值与儿童创伤严重程度和执行功能障碍的相关性。用威斯康星卡片分类测验和Stroop颜色词测验评估儿童创伤受试者的执行功能受损。受伤者右侧楔前叶的FALFF增加，右侧颞叶上回的FALFF减少。在整个样本中，特定的儿童创伤严重程度与执行功能障碍和右侧楔前叶的fALF值显著相关。此外，童年创伤患者在默认模式下与左侧前额叶腹内侧皮质、左侧眼眶前额叶皮质和右侧小脑的基于楔前叶的连接性也有所减弱。默认模式网络连通性降低也与儿童创伤严重程度和执行功能障碍有关。目前的发现表明，童年创伤与执行缺陷和异常的默认模式网络功能有关，即使在健康的成年人中也是如此。此外，这项研究表明，执行功能障碍与默认模式网络连接中断有关。
The aim of this study was to investigate the relationship among childhood trauma, executive impairments, and altered resting-state brain function in young healthy adults. Twenty four subjects with childhood trauma and 24 age- and gender-matched subjects without childhood trauma were recruited. Executive function was assessed by a series of validated test procedures. Localized brain activity was evaluated by fractional amplitude of low frequency fluctuation (fALFF) method and compared between two groups. Areas with altered fALFF were further selected as seeds in subsequent functional connectivity analysis. Correlations of fALFF and connectivity values with severity of childhood trauma and executive dysfunction were analyzed as well. Subjects with childhood trauma exhibited impaired executive function as assessed by Wisconsin Card Sorting Test and Stroop Color Word Test. Traumatic individuals also showed increased fALFF in the right precuneus and decreased fALFF in the right superior temporal gyrus. Significant correlations of specific childhood trauma severity with executive dysfunction and fALFF value in the right precuneus were found in the whole sample. In addition, individuals with childhood trauma also exhibited diminished precuneus-based connectivity in default mode network with left ventromedial prefrontal cortex, left orbitofrontal cortex, and right cerebellum. Decreased default mode network connectivity was also associated with childhood trauma severity and executive dysfunction. The present findings suggest that childhood trauma is associated with executive deficits and aberrant default mode network functions even in healthy adults. Moreover, this study demonstrates that executive dysfunction is related to disrupted default mode network connectivity.
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影响因子：
4.2
作者：
Marusak, Hilary A.;Etkin, Amit;Thomason, Moriah E.
通讯作者：
Thomason, Moriah E.
影响因子：
3.7
作者：
Fransson, Peter;Aden, Ulrika;Lagercrantz, Hugo
通讯作者：
Lagercrantz, Hugo
DOI：
10.1111/jcpp.12409
发表时间：
2015-11
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Graham AM;Pfeifer JH;Fisher PA;Carpenter S;Fair DA
通讯作者：
Fair DA
影响因子：
4.6
作者：
Hanson JL;Adluru N;Chung MK;Alexander AL;Davidson RJ;Pollak SD
通讯作者：
Pollak SD
影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
Zule, W