嗅觉障碍严重影响患者的学习、生活和工作，炎症性嗅觉障碍占嗅觉障碍患者的30%以上。糖皮质激素（GC）是主要药物，但是，仍有相当一部分的患者治疗效果不佳。我们前期实验发现，GC对嗅神经的影响集中于炎症、Axon Guidance 和cell projection等几个关键信号通路。同时，糖皮质激素的作用大多通过其受体GR介导，GR多态性可能是激素治疗是否有效的关键因素。我们在本研究中拟对比激素治疗炎症性嗅觉障碍成功和失败患者GR基因型，寻找导致炎症性嗅觉障碍GC治疗无效的GR基因型；并在细胞学实验验证其对GC的生物学功能的影响；动物模型验证其是否造成炎症性嗅觉障碍治疗时的GC抵抗。以期深入了解GC治疗炎症性嗅觉障碍的机制，而且可能为下一步干预这些通路，避免激素的负面效果，更好的治疗嗅觉障碍提供实验依据。

Olfactory disorders seriously affect the learning, living and working of the patients, inflammatory olfactory dysfunction accounted for more than 30% of patients with olfactory disorders. Glucocorticoids (GC) is the main drug, but there are still a considerable number of poor treatment of patients. Our previous study show, effect of GC on olfactory nerve focused on several key signaling pathways, e.g.inflammation, Axon Guidance and cell projection. Simultaneously, the effects of glucocorticoid are mediated mostly through receptor GR, GR polymorphism may be the key factor whether hormone therapy is effective. In this study, we intend to contrast GR gene polymorphism of patients with inflammatory olfactory disorders between effective and ineffective hormonal treatment, search for the GR genotype of the GC resistance for the treatment of inflammatory olfactory dysfunction.Observe its effect on the biological function of GC.Confirm it can cause GC resistance for treatment of inflammatory olfactory dysfunction. We will understand the mechanism of GC in treating inflammatory olfactory disorders, and to provide a new target for the treatment.