本项目拟开展不对称C-H键官能团化构建平面手性二茂铁化合物的研究。发展钯催化的Cp-H键不对称官能团化反应方法学，从相对廉价易得的二茂铁化合物出发，高对映选择性地合成一类具有潜在应用价值的平面手性二茂铁化合物，为实现高效的不对称催化反应提供各类手性配体或手性催化剂，也为药物发现提供众多候选分子。同时通过计算化学研究反应活性以及对映选择性控制的规律性。

This project focuses on the development of enantioselective synthesis of planar ferrocenes via C-H bond functionalizations. Palladium catalyzed highly enantioselective Cp-H bond functionalization will be developed to provide a variety of potentially useful planar ferrocenes from readily available ferrocene compounds. It not only offers a variety of efficient chiral ligands or chiral catalysts for asymmetric catalytic reactions, but also provides numerous candidate molecules for drug discovery. Mechanistic studies on reactivity and enantioselectivity will be also carried out by DFT calculations.