有机催化的不对称去芳构化反应研究

本项目拟通过两种不同策略-自身氧化还原反应和原位傅克反应来研究芳香化合物包括杂环芳烃和酚类芳烃的不对称去芳构化反应，合成一系列手性的螺环化合物；同时通过计算化学研究有机催化不对称去芳构化反应中芳香化合物的结构与反应活性、对映选择性控制中的规律性。

This project focuses on the development of organocatalyzed asymmetric dearomatization reactions for aromatic compounds including hetero-arenes and phenols via two different strategies- redox reaction and ipso-Friedel-Crafts reaction, affording a series of chiral spiro compounds. Mechanistic studies on organocatalyzed asymmetric dearomatization reactions including the structure of aromatic compound, reactivity and enantioselectivity, will be carried out by DFT calculations.