采用组织工程构建神经导管引导神经再生已成为当前促进神经修复的主要研究方向。如何设计优化神经导管并实现商业转化应用一直是该领域的研究热点。基于上述背景，本项目拟以优选构建神经导管的最佳材料组合为基础，在“结构仿生”概念的指导下，以仿生天然周围神经组织的空间结构为突破点，采用多项技术相结合设计并构建结构可控的三维仿生人工神经导管支架。通过调控材料的降解周期，解决人工神经导管降解速率与新生神经组织再生速率不匹配的问题，以实现周围神经组织的原位再生。同时，对该神经导管进行促血管化和导电性的协同修饰，解决人工神经导管移植后血管再生能力有限及电生理信号传导欠佳的问题。通过神经移植实验，系统认识生物材料、结构设计及功能化修饰对神经再生的协同作用机制，并根据其诱导神经再生的效果优化神经导管的性能，以获得具有临床应用前景的人工神经导管。

It has become the main research direction to enhance the nerve repair by using constructed nerve conduit to guide nerve regeneration. How to design and optimize nerve conduit to facilitate the nerve regeneration and achieve the translation of the commercial applications have been the research focus in this field. In this study, this project is intended to optimize the best material combination for the nerve conduit construction. Under the guidance of the concept of "structural bionics", to simulate the natural spatial architecture of nerve tissues, a multiscale strategy will be adapted to design and fabricate 3D biomimetic nerve conduit. By regulating the degradation period of materials, the mismatching between the degradation rate of artificial nerve conduit and the regeneration rate of nerve tissue will be solved to achieve the in-situ regeneration of peripheral nerve tissue. Meanwhile, the nerve conduit will be modified with the properties of vascularization and electrical conductivity to solve the problems of limited angiogenesis and poor electrophysiological signal conduction after the transplantation of nerve conduit, respectively. Through the nerve transplantation experiment, the synergistic mechanism of biomaterials, structural design and functional modification on nerve regeneration will be systematically understood. In order to acquire some nerve grafts with clinical application prospects, the construction condition of nerve conduits would be optimized according to evaluation results.