再生缺血梗死心肌目前仍然是一个医学难题。最近我们率先报道：新近发现的心肌层间质细胞――"心脏Telocytes（CTs）"所形成的网状结构在心肌缺血时被破坏，对缺血心肌实施CTs移植能有效减小缺血心肌的梗死面积及改善缺血心脏的功能。我们刚被接受发表的文章进一步揭示：经移植入缺血心肌的CTs是通过促进心肌层血管新生、减小缺血心肌纤维化及促进缺血心脏CTs网状结构的重构，从而实现减小梗死心肌面积及改善缺血心脏功能。本项目将在上述原创发现的基础上，进一步阐明：①CTs有效促进缺血心肌血管新生及减小纤维化的分子机理；②CTs在缺氧环境易于死亡的分子机理；③CTs与干细胞联合应用可能更有利于梗死心肌再生的疗效及机理，为全面阐明CTs在心肌层及损伤心肌的修复与再生的功能角色，打下重要基础，同时也为有效再生梗死心肌这一科学及临床难题带来新的思路、靶点、机理及手段。

Regeneration of infarcted myocardium is still a big challenge in clinic. Recently, our team firstly reported that cardiac telocyte network in myocardium is destroyed during the myocardial infarction (MI). In addition, transplantation of cardiac telocytes (CTs) in MI is able to decrease infarcred size and improve cardiac function. Further more, our up-to-date published paper reported that the cellular mechanism of the CT-therapy for MI is promoting the angiogenesis and CT-network reconstruction, and decrase fiborsis in ischemic myocardium to decrase infarct size and improve cardiac function. The proposed study therefore to be designed to further investigate the following critical issues: ①the molecular mechanism of CT-therapy for the promoting myocardial angiogenesis and decrasing fibrosis in MI; ②the molecular mechanism of CT death in ischemic myocardium duing MI; ③the therapeutic effect of CTs combined with adult stem cells for MI. The results of this study will reveal the functional roles of CTs in myocardium and regeneration of injured myocardium. In addition, the findings from this study will shed light for us to establish novel strategy and targets to regenerate the infarcted myocardium.