可见光诱导轴手性分子的催化不对称合成

在温和条件下实现轴手性分子的高效、精准及多样性合成具有重要的理论意义和广阔的应用前景。本项目拟结合可见光诱导的光氧化还原催化与有机催化、Lewis酸碱催化以及过渡金属催化的优势，建立高效、高选择性的协同催化体系并发展可见光驱动的催化不对称反应，合成具有重要应用价值的轴手性分子。重点研究：可见光诱导的不对称Minisci反应研究、可见光诱导氮自由基的不对称串联反应研究、可见光诱导的不对称成环反应研究以及可见光诱导的（动态）动力学拆分和不对称去对称化反应研究。同时，深入研究并总结相关反应的规律与立体控制机制，为开发适用于激发态过程的手性催化剂和催化体系提供依据。本项目的研究工作将进一步推动不对称催化与合成、可见光驱动的有机合成等重要领域的发展，为我国化学化工技术升级与改造提供高质量的研究人才与基础性的研究成果。

The mild-condition synthesis of axially chiral molecules in a highly efficient, selective and divergent manner is of great theoretical significance and has wide applications in chemical synthesis. For this purpose, this project plans to develop high efficient and selective synergistic catalytic systems by combining visible light photoredox catalysis with asymmetric organocatalysis, Lewis acid catalysis and transition metal catalysis, and then apply them to the preparation of axially chiral molecules of potential synthetic values. This research will be focused on the visible light-induced asymmetric Minisci reactions, the visible light-induced asymmetric cascade transformation of N-radical intermediates, the visible light-induced asymmetric cyclization reactions and the visible light-induced (dynamic) kinetic resolution and asymmetric desymmetric reactions. Meanwhile, the investigation and summary of reaction and stereocontrol mechanism will be performed with the hope of helping to exploit chiral catalysts and catalytic systems that can be applied to excited state processes. It is believed that, the successful implementation of this project will promote the development of asymmetric catalysis and synthesis, as well as the visible light-driven organic synthesis, and will provide research talents of high quality and basic research results for the upgrading and transformation of chemical technology in China.