可见光是一种清洁的、可再生的自然资源。研究可见光照射下、光氧化还原催化剂催化的可控自由基反应及其在药物分子和天然产物合成中的应用具有重要的理论意义和应用前景。本项目中拟重点研究1）高效的可见光催化体系；2）发展温和条件下可见光催化的可控自由基反应，包括自由基的氧化-环化串联反应、分子内自由基环化反应、串联的烯烃交叉复分解-自由基环化反应、基于氧化猝灭机理的自由基反应、自由基参与的碳-氢键活化以及羰基化反应；3）探讨控制自由基反应立体选择性的新途径；4）实现可见光催化的自由基反应在药物分子和具有重要生物活性的天然生物碱合成中的应用。通过这些研究，开发具有自主知识产权的可见光催化剂和可见光催化技术，促进我国有机合成反应的研究与发展，提高我国在可见光催化及活泼中间体化学研究领域的国际学术地位，推动可见光催化的可控自由基反应在相关化学工业中的实际应用。

The development of green and sustainable methods for the effective synthesis of fine chemicals and natural products is an important goal in our society. Visible light photoredox catalysis has shown great promise as a method to advance these goals. Due to its high natural abundance, benign environmental impact, cleanliness and sustainability, photocatalytic controlled radical reactions using visible light are a reliable and powerful tool. In this project, we will focus on 1) the development of new and highly efficient visible light photoredox catalysts; 2) the development of visible light photocatalytic controlled radical reactions, including tandem oxidation-cyclization reactions of nitrogen-containing radicals, intramolecular annulation reactions of radicals, tandem CM-radical cyclization reactions, C-H activation and carbonylation reactions wherein radicals involve, and new radical reactions based on oxidative quenching mechanism; 3) exploring new methodologies to control the stereoselectivity of radical reactions, and 4) the application of radical reactions in the synthesis of drug molecules and natural products. During the course of these studies, we will carefully explore the posible pathway of the above-mentioned transformations. By doing so, we will try to invent new photoredox catalysts and photocatalytic technologies with self-owned intellectual property, advance the research and development of novel organic reactions, improve our level in the chemistry of visible light photocatalysis and active intermediates, and push forward the applications of visible light photocatalytic radical reactions in the corresponding industries.