可见光是一种无污染且可再生的自然资源，利用光氧化还原催化剂在可见光照射下催化有机合成转换是最近才兴起的、并具有一定挑战性的研究领域。本项目拟将可见光光氧化还原催化策略用于含氮杂环的合成，重点研究：1）可见光催化的吲哚及其衍生物化合成；2）可见光催化的内酰胺合成；3）可见光催化的多取代吡咯衍生物合成；4）可见光催化的含氮稠杂环合成；5）通过现代化学分析方法进行机理研究和新试剂、新反应的设计；6）尝试以光催化反应为关键步骤实现氮杂环天然产物(±)Sesamin的全合成。重点解决可见光金属催化剂对底物的活化及如何提高反应效率和选择性控制等问题。通过这些研究，力图为结构多样且具有潜在生物活性的含氮杂环化合物的合成提供一条环境友好的绿色化学新途径。本项目的实施对清洁可再生能源的有效利用、新反应方法学的发展、分子复杂性的快速构建并从源头消除或减少废物排放具有重要意义。

The development of new and highly efficient strategies for the rapid construction of intricate molecular architectures is of great importance and remains a preeminent goal in current synthetic chemistry. Recently, the use of visible light to initiate organic ractions has attracted much attention because of its natural abundance, ease of use, non-toxicity and potential applications. In this project, we will focus on the synthesis of N-heterocycles using the strategy of visible light photocatalysis. In this regard, we will investigate 1) a visible light photocatalytic strategy to construct indoles; 2) visible-light-induced radical addition/lactamization reaction to prepare various lactams; 3) visible-light-mediated cycloaddition reaction of azirines with alkynes to generate pyrroles; 4) visible light catalyzed [3+2] cyclization reactions to construct fused N-heterocycles; 5) exploring new reagents and reactions by carefully investigating the mechanism of the above-mentioned transformations; and 6) the total synthesis of natural product, (±)Sesamin, through a photocatalytic [3+2] cyclization reaction as the key step. The performance of these studies will provide a new and green route to nitrogen-containing heterocyclic compounds which have remarkable bioactivities.