暗色真菌广泛存在于自然界中，主要引起着色芽生菌病和暗色丝孢霉病等，难治愈、高危险且发病率也在逐年上升，已引起学界的广泛关注。本课题组的前期研究提示，暗色真菌中可能存在进化地位相对独立的高致病性谱系，该谱系与环境来源的菌株存在明显的遗传差异。因此，本研究借助基因组学的理论和技术，从系统发生动态和宿主适应性进化的角度，聚焦于高致病性暗色真菌的三个代表性物种（疣状瓶霉、皮炎外瓶霉、棘状外瓶霉），通过比较不同物种之间存在的共同基因特质，对暗色真菌的高致病力相关性状做出解析，着眼于两个关键性的科学问题：从系统发生动态的角度，探讨暗色真菌在致病性、流行趋势和系统发生地位之间是否存在相关性；从适应性进化的角度，探讨高致病力暗色真菌，是否在宿主免疫压力的选择作用下形成基因水平的趋同进化，以及这些基因与致病力的关系。

Black yeast widely exists in nature, which mainly causes chromoblastomycosis and phaeohyphomycosis. These diseases are drawing more and more attention from clinician due to its dangerousness and intractability. Our early studies suggested that there were some highly pathogenic lineages with relatively independent phylogenetic status. There was significant genetic difference between strains from clinic and environment. In this project, we will make an analysis in the three leading species of black yeast (Phialophora verrucosa, Exophiala dermatitidis and Exophiala spinifera) from phylodynamic and adaptive evolutionary perspective by genomics approaches. The evolution of black yeast's pathogenicity will be the focus of our research. Our study aims to demonstrate whether there is significant correlation among pathogenicity， epidemic and phylogenetic status, and whether there is convergent evolution at the genetic level under the selective pressure of host.