近年来，以氢化咔唑为基本骨架的吲哚生物碱（包括akuammiline、apocynaceae、aspidosperma、kopia、strychnos等不同家族生物碱）由于其多样的生物活性和独特的化学结构得到合成化学家的广泛关注，推动了合成方法的创新和复杂天然产物的化学合成。虽然针对该类天然产物结构的合成策略被不断开发出来，极大丰富了对该类天然产物的合成手段，但目前还没有一个通用的合成策略可以实现对含有不同该类骨架的天然产物的集体合成。本课题主要基于我们前期发现的氮杂频哪醇重排反应，实现一个策略对应多种骨架的构建，进而完成对以氢化咔唑为基本骨架的吲哚生物碱的多样性合成（calophyline A、strictamine、akuammicine）。

Functionalized hydrocarbazoles are key structural features of akuammiline, apocynaceae, aspidosperma, kopsia, and strychnos alkaloids. The intricate polycyclic structures and interesting biological activities of these complex natural products have attracted significant attention of synthetic chemists in recent years, leading to innovations in synthetic strategies and stunning achievements in total synthesis. Although some developed methods have tremendously facilitated the chemical synthesis of related natural products, a unified strategy that could allow for the collective total synthesis of structurally diverse hydrocarbazole alkaloids remains to be developed. Herein, we propose a unified strategy to hydrocarbazole alkaloids via our previously developed aza-pinacol rearrangement and its application to the divergent total synthesis of calophyline A, strictamine and akuammicine.