本课题旨在探索针对不同骨架类型的多酚类天然产物和生物活性分子的通用性合成策略，进而完成多酚天然产物的不对称多样性合成：包括calomelanol F 、bullataketals、asperversin A的首次不对称全合成，以及aflatoxin B2和SB-217242的更加简洁不对称合成。我们的核心策略是创新性的利用有机催化的苯酚对位选择性傅克烷基化反应构建高度官能团化的合成前体，进而通过其中的官能团选择性配对反应来构建该类天然产物的多样性骨架。

We propose an unified strategy for the assemble of structurally diverse polyphenolic natural products and bioactive molecules, aiming to achieve the first asymmetric total syntheses of calomelanol F, bullataketals, asperversin A and the more concise asymmetric total syntheses of aflatoxin B2 and SB-217242. Our strategy is to use an unprecedented organocatalytic para-selective phenol Friedel-Crafts alkylation to build the highly functionalized precursors and the subsequent selective functional group pairing reactions to construct the different skeletons of polyphenolic molecules.