若干灯台碱不对称催化全合成研究

最近几年，灯台生物碱在国际合成化学界受到广泛关注，为热点领域。我国知名专家学者也已经做出重要贡献，但该类天然产物合成中普遍遇到的问题，即难以实现催化不对称全合成，国际上报道成功例子只有3例。本项目重点将解决这一难题。基于我们最近在完成minfiensine全合成中取得的研究经验，拟进一步设计，发展新的催化不对称、分子内烯丙基化反应，解决其吲哚骨架的普适性、高效不对称合成。结合对四种目标分子的生源合成的理解和启发，一并完成alistonitrine A, nareline, scholarisine A, strictamine的催化不对称全合成。

Akuammiline alkaloids have been received much attention from the synthetic community recently and became one of the hot fields. Although our Chinese scholars have made significant contributions in this regard, there is still an issue we have not well addressed in the synthesis, that is, how to synthesize these alkaloids catalytically and asymmetrically? In fact, there were only three reports regarding catalytic asymmetric synthesis by overseas groups. We will focus on the solving this issue in the project. Based on the experience acquired from total synthesis of minfiensine, we will design, develop new catalysis systems for the intramolecular allyllic cyclization in the indole skeletons, hoping to achieve the general and efficient routes for akuammiline alkaloids and complete the total synthesis of alistonitrine A, nareline, scholarisine A and strictamine in a collective and biomimetic way.