若干重要吲哚生物碱不对称全合成研究

吲哚生物碱communesin F、perophoramidine、脱卤perophoramidine 和actinophyllic acid是合成界备受关注的明星分子。本申请项目拟突出运用过渡金属Ir-催化不对称反应进行上述分子的全合成。我们设计了分子间串联环化反应，一步构建communesin和perophoramidine的四环骨架，运用相似策略实现前三个目标分子的统一合成。运用前期自己方法学，将分子间烯醇硅醚和吲哚2级醇进行不对称烯丙基化反应，和分子内Mannich环化，高效简洁实现actinophyllic acid的全合成。

The bioactive indole alkaloids such as communesin F, perophoramidine, dehaloperophoramidine and actinophyllic acid are the privilege targets for synthetic chemists. In this proposal, we'll highlight the applications of iridium-catalysis asymmetric allylation to the total synthesis. By using of an intermolecular cascade cyclization of indole derivative, we would construct the tetracycle of the key framework, and by similar manipulations, we would achieve the unified total synthese of the first three of the title alkaloids. Inspired by our previous method, we'll utilize an intermolecular allylation of a silyl enol ether and a secondary allylic alcohol of indole derivative, and an intramolecular Mannich cyclization to complete the concise synthesis of actinophyllic acid.