抗生素Teicoplanin Aglycon全合成研究

Teicoplanin是结构非常复杂、活性相当显著的重要抗生素。本项目拟对其aglycon进行全合成研究，旨在为日后深入研究药物化学打基础。我们发展和运用了特色的Ir-催化不对称合成芳基氨基酸的新方法，并将C-H官能团化逻辑巧妙展示于二芳基大环、氨基酸的构建策略中，是合成方法学的创新技术灵活运用在复杂分子全合成的新尝试。

Teicoplanin is a member of a large family of glycopeptide antibiotics which has challenging strututal features and significant bioactivities. In this project, we will investigate the total synthesis of teicoplanin aglycon in order to lay the groundwork for its future medicinal studies. We develop a new methodology of iridium-catalyzed asymmetric synthesis of amino acids. By taking advantage of Ir-catalysis and C-H logic to diaryl macrocycle and amino acids, teicoplanin aglycon would be constucted in a much more efficient way.