生物质燃烧排放是大气颗粒物中重要成分棕碳（BrC）的主要来源之一。关中地区细颗粒物污染是全国最为严重的区域之一，生物质是该地区农村家庭的主要燃料。由于BrC细及超细粒径的富集特点和化学成分的复杂性与毒性，亟需开展生物质燃烧排放主导的BrC引发的健康毒性效应和流行病学研究。本项目拟在关中地区农村使用颗粒物个体暴露采样器对长期生活在生物质燃烧环境中的家庭主妇进行不同粒径颗粒物的采集及流行病学调查，采用先进的七波段DRI2015热/光碳分析仪快速准确地测量低含量多粒径的人体暴露BrC的浓度分布，查明不同固体燃料和燃烧方式对BrC人体暴露的影响及其与造成细胞损伤的活性氧簇（ROS）和流行病学、毒理学指标的定量关联，探讨不同粒径BrC对呼吸和心血管系统的影响，尝试查明BrC健康负效应的毒理学机制。该研究将提高我们对BrC潜在环境影响和致病机制的认识，为我国北方农村居民健康防护提供研究案例和科学建议。

Biomass burning is one of the important sources to Brown Carbon (BrC), which is the important species of particulate matters (PM). Guanzhong Plain is one of the major areas in which the air quality is heavily polluted by the high PM concentrations. The biomass is used as the main heating fuel in most rural households in this area. Due to the fine and ultrafine particle size distribution characteristic of BrC, and complexity and toxicity in its chemical compositions, the toxicological effects for human from BrC emitted from the biomass burning, as well as the related epidemiologic study need to be studied urgently. In this proposal, personal exposure sampling and epidemiological survey will be carried out for housewives who stayed in the biomass combustion environment for long time in Guanzhong rural area. An improved seven-wavelength DRI2015 thermal/optical carbon analyzer will be applied for rapid and accurate analysis the concentrations of low-content and different particle sizes personal exposure BrC. This work aims to estimate the influences of varied burning ways and biomass fuels to the personal exposure BrC and the quantitative correlations with the reactive oxygen species (ROS) and epidemiological indexes, to investigate the effects of different particle sizes BrC on respiratory and cardiovascular systems, and try to find out the toxicology mechanism of BrC to human. This research will enhance our understanding on the BrC potential environmental and health impacts, provide basic data and scientific advice for the rural residents for individual health protection in Northern China.