非对称浸润性界面材料的设计及其伤口渗出液定向移除研究

如何实现伤口的快速愈合，一直是人类健康面临的科学难题之一。尤其是过量或持续的伤口渗出液往往导致伤口愈合困难，例如烫伤等，这也使界面渗出液的有效移除成为伤口敷料设计中的难点和挑战。本项目将围绕界面液体定向输运的基本科学问题，设计材料拓扑结构和表面浸润差异，通过微纳复合加工技术，制备系列非对称浸润性界面材料，以期构筑液体定向导出层状复合材料体系；利用光学显微镜、激光共聚焦荧光显微镜及环境扫描显微镜等技术研究非对称浸润性复合材料的液体定向导出规律，并尝试建立界面液体导出新模型；以大鼠皮肤烫伤伤口为模型，研究所制得非对称浸润性层状复合材料的伤口渗出液导出性能，较传统敷料以期实现伤口渗出液的高效导出（导出率90%以上）以及快速（伤口闭合时间减少20%）的伤口愈合。本项目有望突破传统敷料难以有效移除过量渗出液的难题，发展制备新型功能伤口敷料的新方法和渗出液导出新模型。

Accelerated wound healing is a long-standing challenge threatening public health. Especially, the excessive and continuous exudate always hinders wound healing, like burn wounds. Therefore, effective draining the exudate becomes a difficult challenge in dressing designing. This project will focus the basic science problem of interfacial liquid directional transportation, design the topological structure and wettability differences. By using micro-nano machining technology, we plan to fabricated a serious of layered composite materials with asymmetric wettability to construct liquid directional transportation system. Moreover, the principle of liquid directional transportation by the asymmetric-wettability composite materials will be studied with the assistant of optical microscopy, laser scanning confocal microscopy and environmental scanning microcopy to establish new model of interfacial liquid draining. On the burn wounds of the mouse skin, the prepared layered asymmetric-wetting material is expected to realize effective exudate draining (over 90% draining rate) and accelerated wound healing (wound closure time decreases 20%). This project will solve the problem of effective transporting the excessive exudate, develop new functional dressings and new exudate transportation models.