等亮度正弦光栅颜色视诱发电位的色觉机理研究及相关软件应用基础研究

获得性色觉障碍患者如得不到早期诊断和治疗，往往导致严重而永久的视功能障碍。近来研究发现颜色VEP可以更好的提示视觉通路损伤，可早期诊断疾病，为视路疾病检测提供了新的方向。本研究拟突破以往棋盘格刺激模式局限，设计新型等亮度正弦光栅颜色VEP刺激模式,并针对M、P、K三条通路各自的特性，分别建立光学模型并计算该刺激模型对三种椎体细胞的刺激度，进而确保颜色VEP针对性刺激单条视觉通路，深化色觉视功能检测，建立客观准确的色觉检测系统。首次联合颜色VEP检测和FD-OCT形态学检测、视野检测等，更好的掌握疾病病理生理变化，深入了解疾病发展机制。本研究突破临床心理物理学色觉检测方法，可针对单条视路功能进行检测评估，实现对色觉障碍人群客观定量的检测分类以及疾病的早期诊断，达到对眼色觉功能全面客观评价的目标，具有较高的科学价值和临床意义。

Color vision is one of the important visual functions of human. The early detection of acquired color vision deficiency is very necessary，otherwise，the disease will go on rapidly, which may lead to severe vision loss. The chromatic VEP, which assesses the integrity of the neural pathways responsible for colour vision, is a useful electrophysiological indicator of early colour vision changes.The Chromatic VEP provides a new direction for color vision detection According to the different characteristic of the three pathways, we make a model for equilumant chormatic VEP stumilus. Stimuli were equiluminant horizontal sinusoidal gratings. Chromatic modulation was performed along the L-M (red-green) and S-(L + M) (blue-yellow) cardinal axes of color vision（ie P and K pathway）, in order to selectively influence the activity of the corresponding opponent mechanism or L-, M- and S cone classes. High temporal frequency chromatic VEP stimulation was used to detect congenital red-green color deficiency through L+M pathway and "Equiluminance turning curve" were established according to measurements at the each luminance conditions. We use low temporal frequency stimulation for acquired color vision deficiency through chromatic pathway. At the same time, combine these results of FD-OCT, perimetry and Chromatic VEP test provides a better understanding of the pathophysiology of visual involvement in acquired color vision deficiency. The method overcomes the limits of all the traditional subjective methods used in clinical practice, fulfills the impersonal and quantitative requirements in color vision deficiencies test. Except that it distinguishes the dichromats and the anomalous trichromats efficiently, it also makes a foundation for the future research of color vision deficiencies.