基于OCT气冲印压技术的眼前节组织生物力学测量方法的建立与应用研究

针对眼科临床中缺乏眼前节组织生物力学测量方法的现状，为解决角膜与晶状体弹性相关疾病的诊断与鉴别诊断，并且指导角膜与晶状体屈光手术，增进手术效果，避免严重并发症的发生，本项目拟采用自主研发的气冲印压法结合光学相干层析成像（OCT）技术测量眼前节组织弹性的方法对相关临床问题进行研究，通过离体实验调试操作技术与方法，通过动物实验制定测量的安全剂量标准，通过临床前期实验给出正常人群的测量值范围以及相关疾病的诊断标准。前期工作已由香港理工大学设计并搭建角膜弹性测量样机，实验结果初步表明此方法用于角膜弹性测量可行。本项目的顺利实施将建立和进一步完善该项创新技术的各项参数、指标及标准，为临床应用奠定坚实基础，不仅将填补相关医学方法学的空白，更具有重要的临床意义。该方法还可能有更广阔的临床应用前景，比如：在活体对晶状体小带松弛与断裂、晶状体脱位、眼表肿物的定性诊断等进行无创检查。

For the lack of biomechanical measurement methods of anterior segment of the eye, to address the diagnosis and differential diagnosis of the related diseases of cornea and lens flexibility, as well as the guidance of the cornea and lens refractive surgery to improve surgical results and avoid serious complications, the project intends to innovative use of optical coherence tomography (OCT) based air jet indentation technology to measure the elasticity of the anterior segment of the eye. Debugging operation techniques and methods through vitro experiments. Safe dose measurement standards developed through animal experiments. Given the range of measured values of the normal population and the disease diagnostic criteria though pre-clinical experiments. For the preliminary work, Hong Kong Polytechnic University has designed and built the corneal elasticity measurements prototype. The experimental results initially indicated that this method for corneal elasticity measurements was feasible. The successful implementation of this project will build and further improve the parameters, targets and standards of the innovative technology. And to lay a solid foundation for clinical applications. The OCT based air jet indentation technology will not only fill the gap related medical methodology, but also has important clinical significance. The method also may have broader clinical application, such as: noninvasive examinations in vivo qualitative diagnosis of relaxation and rupture of the suspensory ligament of lens, lens dislocation, ocular surface tumor.