如何高效简便的合成出结构丰富、生理活性显著、数量庞大的碳/杂环化合物集合体，获得一个优质的样品库，是农药筛选的基础，也是合成方法学研究长期面对的挑战性课题。课题组历经十余年的努力，初步实现“基于I2/DMSO组合体系介导下的杂芳环结构体合成反应工具箱”的构建，为获得多样性杂环分子样本库提供一条新的解决途径和策略，相继从中筛选出具有良好除草活性和抗稻瘟病的新型结构体，有望成为潜在的先导性农药分子，实践检验表明这一合成策略具有良好的合理性。本项目是为进一步完善该反应体系的拓展性课题，期望扩容成更加宽泛的杂环合成方法，使得该分子库结构类型更加丰富优异：一是继续探索芳基甲酮甲基形式上的碳氢官能团化反应，接枝上氰基（CN）、烯炔基等功能团，从而转化成具有多个反应位点的合成砌块，为合成新型杂芳环结构体提供有效的中转分子片段；二是探索用天然氨基酸、苯丙素、有机酚、有机烯炔等小分子替代芳基甲酮为起始物在碘

The efficient and concise synthesis of a high-quality library of carbon/heterocyclic compounds with diverse structures, excellent physiological activities, and large quantities is not only the basis of pesticide screening, but also a long-term challenging topic in synthetic methodology research. After a decade’s effort, our group has developed a synthetic tool-box based on the “I2/DMSO-mediated synthesis of (hetero)aromatic compounds”, which provides a new route and strategy for constructing of a library of diverse heterocyclic molecules. We have screened out a series of new molecular skeletons with excellent herbicidal activity and resistance to rice blast, which can become lead compounds for pesticides development. These results verify that our synthetic strategy is promising in development of new pesticides. This project is an important extension of the previous reaction system and is expected to establish various synthetic methods heterocycles with broad substrate scope and diverse molecular skeletons. First, we will continue to explore the functionalization method of aliphatic C-H in the aryl methyl ketone group by decorating with cyano, alkene, and alkyne groups, which will provide a series of synthetic building blocks with diverse reaction sites and synthetic intermediates for preparation of novel heteroaryl structures. Second, we will explore novel heterocyclic synthetic methods based on I2-DMSO mediated reactions starting from natural amino acids, phenylpropanoids, phenols, alkenes, and alkynes, which can be used for preparation of complex molecular skeletons with fused and bridged rings. We will further establish more examples in total synthesis of natural products with one-pot self-organizing strategy and explore the universality of the reaction system. Based on these strategies, we will develop a much more powerful synthetic toolbox and screen out more lead compounds for pesticides.