本项目针对目前PCL类聚酯存在结构单一，难以实现多功能集成的难题，利用含硒化合物具有的独特化学反应，设计合成含有苯基硒醚功能化的内酯单体，探索将该单体作为“合成子”，结合点击化学、杂化聚合等方法，开展含有功能性基团聚酯结构的可控合成研究，实现聚酯材料的功能集成，为该类聚合物的应用提供灵活、便利的合成方法。与现有改性方法相比，本项目拟采用的方法具有以下优点：1）功能化方式丰富，可以由一种苯基硒醚功能化内酯出发，通过不同的反应途径获得丰富功能化集成的聚酯材料；2）反应条件温和，对主链中敏感的酯基影响甚微，最大程度避免了功能集成过程中可能存在的主链降解问题；3）改性过程中充分运用当前高分子合成中的新型高效反应，对聚合物结构具有优异的可控性，可以实现聚合物的合成设计。

Aliphatic polyester has received great attention in recent years because of its good biocompatibility, good mechanical properties, and excellent biodegradability through hydrolysis as well as enzyme catalytic degradation. However, because of the hydrophobic and semi-crystalline nature, low degradability, and especially the lack of functional groups, its biomedical applications are limited. As the result, the introduction of functional groups into these polyester chain is one of hot topic in this fields for the aim of such as increasing the hydrophilicity, adjusting the degradation rate, decreasing the crystallinity etc. Different kinds of reactions have been developed to realize such modification. Typical reactions such as Baeyer-Villiger oxidation, electrophilic substitution reaction, and hybrid polymerization etc. However, the rigid reaction conditions and limited functional groups for one reaction are far from enough for developing high performance materials. .With such situation in mind, the aim of this proposal is focused on developing novel way to solve such difficulty by introducing selenide contained structures onto lactone. Using such selenide-functionalized lactone as novel "synthesis", multifunctional groups could be integrated with polyester main chain through the unique chemical reaction of selenide combining with the click chemistry and hybrid polymerization methods. The current method shows advantages as following: 1) versatile functionalization abilities could be derived from one simple selenide functionalized lactone monomer by adjusting reaction conditions; 2) mild reaction conditions would be favored for non-disturbing sensitive ester structure within main chain of polyester, which could avoid the possible degradation during modification; 3) by the combination of efficient reactions, such as Click reaction and controlled radical polymerization, it offered the ability for synthesis polymers with controlled structures. These advantages would be valuable for developing versatile functional polyester with controlled structures adjustable properties.