信号分子IKKα 作为炎症信号通路中的关键节点，在炎症相关疾病中起着十分重要的作用。染色质重塑蛋白LSH和长链非编码RNA HOTAIR可能在炎症因子和DNA损伤反应（DDR）基因调控中起着十分重要的作用。我们将以鼻咽癌为研究模型，在放射处理引起的DDR过程中，EBV编码的瘤蛋白LMP1一方面使IKKα从炎症因子的启动子区释放出来，从而上调炎症因子的表达水平，增加DNA损伤修复基因的表达水平；LMP1另一方面通过染色质重塑蛋白LSH及LincRNA HOTAIR之间的染色质转录调控整合上调DNA损伤修复基因的表达水平，导致DDR修复能力增强，最终导致LMP1表达的细胞具有明显的放疗抵抗性。通过上述研究将从一个新的研究方向阐明炎症在肿瘤DDR及修复过程中的机制，为肿瘤的放疗提供新思路。同时对于靶向染色质重塑蛋白及炎症因子的阻断剂联合放疗增敏提供重要的临床和应用的理论依据。

Signaling molecule Iκ B Kinase alpha (IKKα ), a key node in the network of inflammatory signal, plays an important role in inflammation-related diseases. Chromatin remodeling factor lymphocyte specific helicase (LSH) and lincRNA HOTAIR may play a critical role in inflammation and DNA damage repair related genes. We will define nasopharngeal carcinoma as a model and we will focus on the key nodes of IKKα , the key molecules of the network signal, and chromatin remodeling protein LSH, researching on the radiation treatment-induced DNA damage response (DDR) process from genome-wide level and signaling transduction network. We may find that, on the one hand, it could induce the increase of inflammatory factors after the activation of IKKα signaling pathways via the release of IKKα from the chromatin; the other hand, it could affect the expression profile level of the DNA repair genes by the transcriptional integrated regulation of chromatin remodeling protein LSH and LincRNA HOTAIR. We will also clarify the new mechanisms of inflammatory network in tumor DDR process from genomics level and from the point of view that combining the signal transduction networks and genetic chromatin remodeling, which will provide new ideas for the radiotherapy of nasopharyngeal carcinoma. Besides, it will have an important clinical significance and application prospects for the development of blockers targeting chromatin remodeling proteins and inflammatory cytokines in sensitizing radiotherapy.