肝脏作为机体重要的解毒器官,在受到物理性和化学性的损伤后，通过肝再生促进肝细胞的增殖补偿损伤的肝组织和恢复肝脏的生理功能进行修复，其中蛋白质的磷酸化调控对肝再生起到了重要的调控作用。蛋白磷酸酶2A（PP2A）是磷酸化丝氨酸/苏氨酸残基蛋白磷酸酶家族中重要的一员，它和PP1调节了细胞内几乎90%的蛋白丝氨酸/苏氨酸的磷酸化。但PP2A调控肝损伤修复中肝再生机制的研究并无人涉及。我们的初步研究发现在肝脏受损伤的病人样品中，PP2AmRNA表达丰度较高；特异性的在小鼠肝脏中敲除PP2A的催化亚基能够分别显著地促进CCL4诱导的化学性肝损伤和70%肝切除诱导的物理性肝损伤修复下的肝脏再生。本课题将从细胞水平、组织水平、动物水平系统地探究在物理性和化学性肝损伤恢复过程中，PP2A通过经典的AKT信号通路或其他的磷酸化信号通路调节肝再生的机制，为应用PP2A作为肝损伤修复的治疗靶点提供理论基础。

As an important organ in the dytoxification system, liver is involved in numerous activations of signal transduction pathways by phosphorylation and dephosphorylation after physical or chemical damage, which is significant in the process of hepatic structural regeneration and functional restoration. Protein phosphatase 2A (PP2A) is an important member of the protein serine/threonine phosphatases family，however PP2A regulation of in liver regeneration mechanism in liver damage repaire is not clarified. Our preliminary study found that PP2A is highly expressed in liver damage patient and liver specific knockout PP2A in mice can significantly promote liver regeneration in CCl4 induced chemical liver damage and 70% liver hepatectomy respectively。We will explore the molecular mechanism of PP2A in regulating the liver regeneration upon liver damage, which may provide a theoretical basis on the treatment for liver diseases by PP2A.