兼具储藏稳定和结肠靶向控释的壳聚糖基包材设计及其机理研究

从功能食品实际应用的角度出发，在活性蛋白的稳态化和生物利用有效性兼顾协调的考虑下，开展适合凝胶食品体系中活性蛋白长期储藏和结肠靶向传输的壳基包载材料筛选设计及其控释系统构建的科学问题研究。选择链结构、聚集态结构合适的壳聚糖基包材，以合适的组装方式与活性蛋白形成聚集体，借助壳聚糖基包材在食品加工储藏过程中的稳定性和在后续人体上消化道环境中的抵抗性，实现活性蛋白长期储藏稳定和结肠靶向传递协调兼顾；通过多种现代分析技术对壳聚糖基包材及其与活性蛋白的微观结构进行表征，掌握相应的变化规律，建立凝胶食品体系中壳聚糖结构与性能的作用机理，获得凝胶食品体系中结构、性能可控的壳聚糖基包载材料及其控释系统的设计，进而为活性蛋白在凝胶食品中长期稳态化和后续生物利用有效性提供理论支撑。研究结果对功能食品的功能作用发挥及新型功能食品开发有科学意义，亦可提高壳聚糖及相关产业的附加值。

Focused on the application of functional food, the steady state and bioavailability of bioactive compound must be taken into consideration together. For the long-term storage and colon target delivery of bioactive compound, the sciencific problem of chitosan carrier material and its controlled-release system in hydrogel food will be developed. With suitable molecular structure, chitosan will be chosen to aggregate with bioactive protein by appropriate way, and it has responsiveness to the condition of food processing and storage in hydrogel food and has resistance to the following upper gastrointestinal tract in the body. The purpose of achieving the long-time steady storage and colon target delivery of bioactive protein together will be achieved. By the modern analysis techniques, the microsturture of chitosan and chitosan-bioactive protein aggregation will be characterized. According to the relationship between chitosan microstruture and its properties, the design of ideal chitosan carrier material and its controlled-release system in hydrogel food will be obtained. These make a theoretical support for the long-term steady state and the bioavailability of bioactive compound in hydrogel food storage. The result of this research program have a scientific meaning in improving the effectiveness and bioavailabillity of functional food and developing new type functional food. Furtheremore, it also have an advantage of enhancing the additional value of chitosan and related industry.