面神经缺损易导致患者颜面部表情肌瘫痪，造成不同程度的面瘫。临床上常用的修复方法包括自体移植、邻近神经吻合术等，但其修复效果难以令人满意。我们前期的研究中发现，利用神经再生组织工程学可有效提高神经再生质量，然而结合低剂量激光和神经再生组织工程学共同构建面神经导管的研究尚无报道。本项目拟通过将光导材料聚1,8-辛二醇柠檬酸酯（POC）与组织工程学材料胶原、明胶和海藻酸钠相混合，并探讨其合成步骤，利用3D生物打印与低剂量激光结合重建面神经。将初步探讨出：1、利用面神经三维扫描拓扑结构为模型，使用多种天然多聚体生物材料和光导材料，实现3D打印光-胶原复合物重建面神经；2、使用低剂量激光实现神经定向生长，研究及探讨神经定向生长的规律或机制。

Facial nerve defects can easily lead to facial mimetic muscles paralysis in patients, resulting in varying degrees of facial paralysis. Commonly used in clinical repair methods including autograft, adjacent nerve anastomosis, while the repair effect is unsatisfactory. Our previous study found that the use of nerve regeneration of tissue engineering can effectively improve the quality of nerve regeneration, however, combined with low lever laser and nerve regeneration of tissue engineering to jointly construct facial nerve conduit has not been reported. This project intends to combine the photoconductive materials as poly 1,8-octanediol citrate (POC) with tissue engineering materials- collagen, gelatin and sodium alginate to explore the synthesis steps to improve the photoconductive properties of nerve scaffolds and reconstruct facial nerve by using 3D printing combined with low level laser therapy. We will initially explore the following aspects: 1. Taking facial nerve three-dimensional scanning topology as a model, using a variety of natural multimeric biomaterials and photoconductive materials to achieve 3D printed light-collagen complex to reconstruct the facial nerve; 2, using low level laser as the guide to achieve nerve orientation growth, research and explore the law or mechanism of nerve-oriented growth.