数字编码悬浮芯片技术研发

作为最新一代的多指标并行检测技术平台，悬浮芯片技术在临床诊断、生物医学（包括基因组学、蛋白质组学）研究等领域都有着广泛的应用，目前已经有超过50个基于该技术的相关产品通过美国FDA认证。本项目旨在研发具有自主知识产权的数字编码悬浮芯片技术，解决现有技术中编码数较少、编码容易改变、工艺复杂等问题。项目的成功实施需要综合运用生物分析技术、微纳加工技术、光学、化学修饰、图像识别等多方面知识，是一个高度交叉的题目，申请人及其团队在生物分析领域从事了多年的研发，有化学、生物和微电子方面的背景，前期已经就该项目进行了原理性实验，验证了该方法的可行性，后期将重点对其性能和应用进行优化和深入的研究。

Multiplex analysis of proteins and nucleic acids from a lot of samples is of great interests for both academic and clinical purposes. Suspension arrays featured with encoded microparticles and a near solution interaction with targets are best suited for detecting hundreds of targets over a large number of samples in a fast and accurate manner. Here, we proposed to develop a proprietary digitally encoded suspension array technology for multiplexed biomolecular analysis. This technology has the advantages of high sensitivity, low cost and high throughput, and may has potential for clinical applications. Based on our previous research work, we have demonstrated its feasibility. Further works will be needed to improve its performance and broaden its applications.